近日，浙江大学第二附属医院眼科的胡江华同学在其发表在Oxidative Medicine and Cellular Longevity杂志的SCI论文“The Function of Thioredoxin-Binding Protein-2（TBP-2）in Different Diseases”的致谢部分，感谢了歌手林俊杰，表示在过去十年里，林俊杰的歌曲给了她强大的精神支持。

致谢部分：

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant nos. 81470612 and 81670832). In addition, Jianghua Hu especially wishes to thank JJ Lin, whose songs have given her powerful spiritual support over the past decade.

有媒体第一时间联系了胡江华同学，胡同学表示其导师俞一波教授也支持她的这一致

谢。

胡同学表示：“作为一个勤勤恳恳的医学科研学术狗，只能通过人生的第一篇SCI论文致谢，来感谢偶像对自己的影响和鼓励”。

当然，胡同学也希望通过媒体传递一个观点，追星不能盲目，偶像所传播的正能量推动着我们不断进步，成为更好的人。

为了成为更好的人，

要不...，

我们...，

我们一起来啃一啃这篇医学论文...

的...摘要部分？

The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases

硫氧还结合蛋白-2(TBP-2)在不同疾病中的作用

Abstract

Thioredoxin-binding protein-2 (TBP-2) has an important role in the redox* system, but it plays a different role in many different diseases (e.g., various cancers, diabetes mellitus* (DM), cardiovascular* disease, and cataracts*) by influencing cell proliferation, differentiation, apoptosis, autophagy, and metabolism*. Distinct transcription factors (TFs) stimulated by different factors combine with binding sites or proteins to upregulate or downregulate TBP-2 expression, in order to respond to the change in the internal environment.

TBP-2在氧化还原系统中起着重要作用，但它在许多不同的疾病(例如，各种癌症、糖尿病、心血管疾病和白内障)中也发挥着不同的作用，影响细胞增殖(proliferation)、分化(differentiation)、凋亡(apoptosis)、自噬(autophagy)和代谢(metabolism)。不同的转录因子(TFs)受不同因素的刺激，结合结合位点或蛋白，上调或下调TBP-2的表达，以响应内部环境的变化。

*redox：a chemical process in which an atom, molecule, etc. either gains or loses electrons 氧化还原反应

*diabetes mellitus 糖尿病

*cardiovascular [ˌkɑː(r)diəʊˈvæskjʊlə(r)] relating to the heart and blood vessels (= tubes that carry blood around the body) 心血管的

cardiovascular disease

心血管疾病

*cataract [ˈkætərækt]

a disease in which an area of someone's eye becomes less clear so that they cannot see clearly, or the area affected in this way 白内障

*metabolism：all the chemical processes in your body, especially those that cause food to be used for energy and growth 新陈代谢

Exercise is supposed to speed up your metabolism.

运动被认为可加速新陈代谢。

Most research disclosed that the main function of TBP-2 is associating with thioredoxin (Trx) to inhibit the antioxidant* capacity of Trx. Furthermore, the TBP-2 located in tissues, whether normal or abnormal, has the ability to cause the dysfunctioning of cells and even death through different pathways, such as shortening the cell cycle andinducing apoptosis or autophagy.

大多数研究表明，TBP-2的主要功能是与硫氧多辛(Trx)结合，抑制Trx的抗氧化能力。此外，在组织中，无论是正常的还是异常的TBP-2，都有能力通过不同的途径导致细胞的功能失调，甚至死亡，例如缩短细胞周期，诱导细胞凋亡或自噬。

*antioxidant：(n.) a substance that slows down the rate at which something decays because of oxidization 抗氧化剂，阻氧化剂，防老（化）剂 (adj.) 抗氧化的

Through these studies, we found that TBP-2 promoted the development of diseases which are involved in inflammatory* and oxidative* damage. To a certain extent, we believe that there is some hidden connection between the biological functions which TBP-2 participates in and some distinct diseases. This review presents only a summary of the roles that TBP-2 plays in cancer, DM, cataracts, and so on, as well as its universal mechanisms. Further investigations are needed for the cell signaling pathways of the effects caused by TBP-2. A greater understanding of the mechanisms of TBP-2 could produce potential new targets for the treatment of diseases, includingcancer and diabetes, cardiovascular disease, and cataracts.

通过这些研究，我们发现TBP-2促进了炎症和氧化损伤相关疾病的发展。在一定程度上，我们认为，TBP-2参与的生物学功能与一些独特的疾病之间存在着某种潜在的联系。本文仅概述了TBP-2在癌症、糖尿病、白内障等方面的作用，以及它的普遍机制。对TBP-2影响细胞信号通路则需要进一步的研究。更深入地了解TBP-2的机制可能会为治疗疾病，包括癌症和糖尿病、心血管疾病和白内障，提供潜在的新靶点。

*inflammatory：causing or related to swelling and pain in the body 发炎的；引发炎症的

*oxidative：An oxidative chemical reaction adds oxygen to the tissues of the body. 氧化的

oxidative damage

氧化损伤

译文来源：Bioworld

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