炎性痛(IB)或神经痛(NP)：

特点以及与AS患者疾病活动度

和功能状态的关联

目 的

评估中轴型脊柱关节炎（axSpA）患者的炎性背痛（IBP）和神经性疼痛（NP），并探讨其与疾病活动度和功能状态的关系。

方 法

评估IBP或NP的存在、疼痛强度和性质、疼痛干扰、疾病活动度和功能状态。 使用单变量分析和二元逻辑回归法确定与IBP或NP相关的因素。

结 果

50名患者（37.9％）患有IBP，22名患者（16.7％）患有NP。 IBP或NP患者的疼痛强度和疼痛干扰、疾病活动度和功能受限的评分显着高于无IBP或NP的患者（P <0.05）。 IBP或NP的性质主要通过感觉描述词表述，IBP患者在情感描述方面具有较高的“疲惫感”（P <0.05）。 IBP与疾病活动度之间存在显著相关性（比值比[OR] = 1.813,95％置信区间[CI] = 1.196-2.750）。 NP与功能受限相关（OR = 1.544,95％CI = 1.098-2.171）。

结 论

尽管IBP或NP患者的疼痛性质（感觉和情感疼痛描述）有差异，合并IBP或NP的axSpA患者均痛感更强、干扰更剧烈、疾病活动度更高、功能受限更明显。在axSpA患者中，合并IBP或NP均反映了更高的疾病活动度和更明显的功能受限。

原 文

Inflammatory or Neuropathic Pain: Characteristics and

Their Relationships with Disease Activity and Functional Status in Axial Spondyloarthritis Patients.

Objective

To assess inflammatory back pain (IBP) and neuropathic pain (NP) in patients with axial spondyloarthritis (axSpA) and explore their relationships with disease activity and functional status.

Methods

The presence of IBP or NP, pain intensity and quality, pain interference, disease activity, and functional status were assessed. Univariate analyses and binary logistic regressions were used to identify factors related to IBP or NP.

Results

Fifty patients (37.9%) had IBP, and 22 (16.7%) had NP. Scores of pain intensity and pain interference, disease activity, and functional limitation were significantly higher in patients with IBP or NP than those without either (P<0.05). The quality of IBP or NP was mainly presented as sensory descriptors, and patients with IBP had a higher level of "tiring-exhausting" in affective descriptors (P<0.05). There was a significant correlation between IBP and disease activity (odds ratio [OR] = 1.813, 95% confidence interval [CI] = 1.196-2.750). NP was related to functional limitation (OR=1.544, 95% CI = 1.098-2.171).

Conclusion

Though pain quality (sensory and affective pain descriptors) show differently in patients with IBP or NP, the axSpA patients with IBP or NP experience more severe pain intensity and pain interference, higher disease activity, and greater functional limitation. The presence of IBP or NP could reflect higher disease activity or greater functional limitation in patients with axSpA.

文章出处：

Ji Y, et al., Pain Med. 17 Jul 2018.

https://www.ncbi.nlm.nih.gov/pubmed/30020521