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安德烈·德朗出生於法國沙東，逝於加爾什。他和弗拉芒克共用一間畫室，19歲時結識馬蒂斯，1905年和馬蒂斯在法國南部一帶旅行作畫，深受馬蒂斯影響，是野獸派的先驅者。

德朗首先發現黑人藝術，認識到民間藝術的豐富和想像的濃郁；他還發現原始藝術、龐貝繪畫、中世紀哥特藝術和文藝復興初期大師們藝術的奧祕。

他研究了古人藝術創造的祕訣，重新踏上他們所走過的路，運用傳統創造現代藝術。大自然是他創作靈感的源泉，博物館中歷代大師之作是他創作的模特。